Santorini has long been synonymous with dreamy escapes, jaw-dropping views, and romantic experiences, and its selection of luxury hotels only enhances the island’s appeal. In 2025, the standards for accommodations have never been higher—with new openings, upgraded facilities, and fresh concepts raising the bar for boutique stays. Whether you’re planning a honeymoon, a once-in-a-lifetime getaway, or simply seeking to be immersed in one of the world’s most iconic island destinations, choosing the right hotel can define your entire Santorini experience. From cave-style suites with private infinity pools to cliffside sanctuaries offering world-class service, here are 10 stunning Santorini hotels you simply cannot miss in 2025.
1. Canaves Oia Epitome – Oia
Canaves Oia Epitome continues to be a standout in 2025 for travelers seeking a blend of traditional Cycladic architecture and modern sophistication. Located just outside the main pedestrian core of Oia, the hotel offers something unique: uninterrupted sunset views over the Aegean without the crowds. Unlike most cliffside hotels facing the caldera, Epitome faces the western side of the island, providing a rare combination of ocean horizon sunsets and expansive privacy. The villas here are luxurious and minimalist, each with its own private plunge pool, outdoor dining area, and interiors that reflect refined Greek simplicity. The Elements Restaurant serves elevated Mediterranean cuisine with a focus on local ingredients, and the tranquil ambiance makes this one of Santorini’s most exclusive escapes.
2. Grace Hotel Auberge Resorts Collection – Imerovigli
Grace Hotel remains one of the most iconic names in luxury hospitality on the island. Perched in Imerovigli—arguably the most romantic village on the caldera—it blends panoramic views, personalized service, and design-forward spaces in a way few other properties can replicate. In 2025, the hotel continues to set the standard for romantic getaways and honeymoon stays. Each room and suite is outfitted with sleek lines, textured whites, and curated Greek decor. The infinity pool, seemingly suspended above the sea, is still one of the most photographed on the island. Dining at the Grace Restaurant is a culinary experience, with a multi-course tasting menu that rivals Michelin-starred establishments.
3. Mystique, a Luxury Collection Hotel – Oia
Nestled into the cliffs of Oia, Mystique remains a favorite for travelers who want to feel embedded within Santorini’s landscape. The property features 41 cave-style suites carved into the caldera’s rock, each offering dramatic views and total seclusion. In 2025, Mystique has enhanced its wellness offerings with a new open-air spa program, featuring sunrise yoga and volcanic stone massages. The décor is organic and earthy, using local materials to create a seamless harmony with the surroundings. A standout feature is the Lure by Olivier Campanha restaurant, which offers one of the island’s most innovative menus, merging Greek flavors with French technique. The hotel’s wine cave, home to rare Assyrtikos and global vintages, offers intimate tastings led by expert sommeliers.
4. Katikies Chromata – Imerovigli
Katikies Chromata is a visual masterpiece—an all-white labyrinth of suites, stairways, and plunge pools clinging to the cliffs of Imerovigli. What sets Chromata apart in 2025 is its effortless blend of tradition and edgy design. The suites are compact but meticulously appointed, with private terraces overlooking the caldera, and some even feature hanging beds and glass-walled bathrooms that add a whimsical modern twist. The infinity pool here is one of the most photogenic in Santorini, with unobstructed views of the volcano. The new rooftop bar, Chromata Sky, serves expertly crafted cocktails as the sky turns fiery orange each evening, making this a must-stay for travelers drawn to chic aesthetics and social ambiance.
5. Andronis Luxury Suites – Oia
A jewel in the Andronis portfolio, Andronis Luxury Suites is known for its top-tier service and otherworldly views. Built into the steep cliffs of Oia, each suite feels like a private sanctuary, with cave pools, indoor-outdoor living areas, and Instagram-worthy terraces. In 2025, the hotel is attracting wellness-conscious travelers with its expanded spa menu, incorporating ancient Greek rituals and aromatherapy tailored to individual needs. The Lycabettus Restaurant, perched dramatically on a rocky outcrop, remains one of the most exclusive dining spots in Santorini, with a tasting menu and wine pairing that draw global gourmands. Andronis Luxury Suites is ideal for those seeking sophistication, serenity, and seamless luxury.
6. Istoria Hotel – Perivolos Beach
For a completely different Santorini experience, Istoria Hotel offers beachfront luxury in a minimalist, bohemian setting. Located on the black-sand shores of Perivolos, it breaks away from the caldera-focused mold and instead celebrates Santorini’s coastal beauty. The hotel’s 12 suites are designed with earthy tones, hand-crafted furniture, and a contemporary nod to traditional island architecture. Several rooms come with private hot tubs or plunge pools. In 2025, Istoria’s onsite restaurant, Mr. E, is drawing attention with a hyper-local menu featuring fresh seafood and rare island herbs. The vibe here is relaxed and unpretentious—perfect for travelers who want chic luxury without sacrificing the beach holiday atmosphere.
7. Cavo Tagoo Santorini – Imerovigli
Cavo Tagoo Santorini continues to captivate with its bold design, dramatic infinity pools, and ultra-modern style. Perched above the caldera in Imerovigli, the hotel is favored by trendsetters, influencers, and honeymooners who seek a more glamorous experience. Each suite features mood lighting, minimalistic lines, and terraces with either heated plunge pools or full-size infinity pools. The 2025 season sees the opening of its brand-new wellness wing, featuring a panoramic yoga deck, hydrotherapy suites, and a range of detox treatments. Cavo Tagoo’s Vezené Restaurant, blending Greek island flavors with contemporary flair, remains a culinary highlight. If you’re looking for a stay that’s both high-end and high-impact, this is your place.
8. Perivolas – Oia
Perivolas is one of the original luxury cave hotels in Oia, and in 2025, it remains a benchmark for understated elegance. Unlike flashier counterparts, Perivolas embraces a philosophy of tranquility and slow living. Suites are carved into the hillside and furnished with handmade pieces, vaulted ceilings, and colorful accents. Many rooms offer private terraces with infinity pools that seem to melt into the sea below. The ambiance here is meditative, with no televisions and an adults-only policy that enhances the sense of retreat. The in-house restaurant offers home-style Greek cuisine and is a favorite among returning guests. Perivolas is perfect for couples seeking serenity and timeless charm.
9. Katikies Garden – Fira
Katikies Garden brings something entirely fresh to the Fira hotel scene. Set in a former monastery with centuries-old architecture, this property blends historical significance with contemporary luxury. Unlike Santorini’s clifftop hotels, Katikies Garden offers a garden sanctuary with a lush courtyard pool, fragrant herbs, and a serene atmosphere rare in busy Fira. Suites are expansive, with vaulted ceilings, mosaic-tiled bathrooms, and plunge pools. The hotel’s Selene Restaurant, one of Santorini’s culinary institutions, is now housed here, offering fine dining with an emphasis on ancient recipes reimagined. If you want central access to nightlife, shopping, and local culture while enjoying a luxurious cocoon, Katikies Garden is a unique and stunning choice.
10. NOŪS Santorini – Mesaria
The most exciting newcomer in 2025 is NOŪS Santorini, a five-star design hotel that’s reimagining luxury in the heart of the island. Located in Mesaria, a lesser-known but strategically central village, NOŪS offers a fusion of modern architecture, art, and wellness. Its 119 rooms and suites include private gardens, pools, and spacious layouts perfect for longer stays. The hotel’s spa is one of the largest in Santorini, featuring an indoor pool, hammam, and treatment rooms inspired by ancient Greek healing practices. NOŪS also doubles as an art destination, with curated exhibitions and installations throughout the property. The culinary offering combines Cycladic purity with avant-garde flair, attracting both travelers and local foodies alike. NOŪS is ideal for design lovers, wellness seekers, and those who want to experience a contemporary take on island life.
Santorini is a destination that continues to evolve while maintaining its core identity of beauty, romance, and serenity. The island’s hotel scene in 2025 reflects this balance perfectly, offering everything from cave-carved retreats and beachfront escapes to bold architectural marvels. Whether you’re watching the sunset from your private plunge pool in Oia, practicing yoga on a caldera deck in Imerovigli, or indulging in a beachside brunch in Perivolos, each of these stunning hotels promises an experience far beyond ordinary accommodation. The only challenge? Choosing just one.
